Seroxyn 50/100 Acucap Capsule

✔️ Uses of Seroxyn 50/100 Acucap Capsule

• Chronic Obstructive Pulmonary Disease (COPD)
• Bronchitis, Asthma
• Emphysema.

✔️ How does Seroxyn 50/100 Acucap Capsule work?

Salmeterol + Fluticasone Propionate is a medication that combines two active ingredients: Salmeterol and Fluticasone Propionate. Salmeterol functions as a long-acting bronchodilator, primarily by relaxing the muscles in the airways, which results in the widening of these air passages. On the other hand, Fluticasone Propionate is a steroid that operates by inhibiting the release of specific chemical messengers responsible for triggering inflammation and swelling within the airways. Together, these two components work synergistically to facilitate easier and more effective breathing.

✔️ Side Effects of Seroxyn 50/100 Acucap Capsule

Expected side effects may include tremors, palpitations, headache, arrhythmias, joint pain, rash, edema, angioedema, oropharyngeal irritation, and muscle cramps.

✔️ Quick Suggestions:

• This medication is intended for inhalation only and should not be swallowed.
• Take it at the same time every day.
• It is not for immediate relief of sudden breathing difficulties; use a rescue inhaler for such situations.
• Dry mouth may occur; alleviate it with frequent mouth rinses, good oral hygiene, increased water intake, or sugarless candy.
• Gargle with warm water after each inhalation to prevent fungal infections in the mouth and throat.
• The first dose should be taken under medical supervision as it may cause immediate bronchospasm (airway tightening) or wheezing.
• Your doctor may monitor your blood potassium levels regularly, as hypoxia and medications like Salmeterol and fluticasone Propionate can lower potassium levels.
• Only trace amounts of Salmeterol + Fluticasone Propionate may enter the bloodstream after inhalation, making serious side effects unlikely.
• Regular blood tests are recommended to check potassium levels due to the potential for low blood potassium (hypokalaemia) with SALMETEROL+FLUTICASONE.
• Monitor blood sugar levels regularly while using SALMETEROL+FLUTICASONE, as bronchodilators like Salmeterol can lower blood glucose.
• If you have diabetes, consult your diabetologist before using SALMETEROL+FLUTICASONE to adjust insulin or other diabetic medications as needed to maintain blood sugar levels.

✔️ Indication of Seroxyn 50/100 Acucap Capsule

This approach has been established as standard care for asthma, particularly when employing combination products that include long-acting beta 2 agonists and inhaled corticosteroids. It is typically recommended for two groups of patients:

Individuals who cannot effectively manage their asthma using inhaled corticosteroids and short-acting inhaled beta 2 agonists on an "as-needed" basis.

Patients whose asthma symptoms have been well-controlled by a combination of inhaled corticosteroids and long-acting beta 2 agonists.

✔️ Pharmacology

Salmeterol+Fluticasone is a medication used to treat asthma and other airway blockages. Salmeterol xinafoate, a long-acting selective β2 agonist, relaxes airway muscles, increasing airflow and alleviating symptoms. Fluticasone propionate, a corticosteroid, locally targets the lungs to reduce inflammation and improve lung function. When used together, Salmeterol+Fluticasone offers a comprehensive approach.

✔️ Dosage & Administration of Seroxyn 50/100 Acucap Capsule

Inhalation Aerosol:

• Adults and adolescents (12 years and older): 2 puffs of 25 µg Salmeterol and 50 µg Fluticasone Propionate twice daily or 2 puffs of 25 µg Salmeterol and 125 µg Fluticasone Propionate twice daily or 2 puffs of 25 µg Salmeterol and 250 µg Fluticasone Propionate twice daily.
• Children (4-12 years): 2 puffs of 25 µg Salmeterol and 50 µg Fluticasone Propionate twice daily.

Inhalation Powder in Capsule (For Asthma):

• Adult and Adolescent (12 Years and Older): Salmeterol 50 µg & Fluticasone 100 µg or Salmeterol 50 µg & Fluticasone 250 µg twice daily.
• Pediatric Patients (4 to 11 Years): Salmeterol 50 µg & Fluticasone 100 µg twice daily.

Inhalation Powder in Maxhaler (For Asthma):

• Adults and Adolescents (12 years and older): Various dosages, one inhalation twice daily.
• Children (4 years and older): One inhalation twice daily.

✔️ Interaction

• Non-selective and selective beta-blockers should be avoided unless necessary.
• Minimal medication interactions due to low plasma levels after inhalation.
• Caution with powerful CYP3A4 inhibitors (e.g., ritonavir, ketoconazole).

✔️ Contraindications

Contraindicated in patients hypersensitive to any ingredients.

✔️ Pregnancy & Lactation

Limited data on use during pregnancy and lactation, benefits must outweigh potential risks.

✔️ Precautions & Warnings

• Consider additional corticosteroid therapy for infections.
• Use with caution in active or latent tuberculosis.
• Exercise caution in patients with thyrotoxicosis.

✔️ Storage Conditions

• Do not puncture, rupture, or incinerate pressurized containers.
• Store below 30°C, away from direct sunlight and high temperatures.
• Keep out of the eyes and reach of children.